Independent reference · Not affiliated with any 7-OH brand
For some people, 7-OH has been genuinely life-changing — meaningful pain relief, a bridge off prescription opioids, an improvement in quality of life that nothing else provided. For regulators, the same compound raises serious questions about dependence, uncontrolled dosing, and a consumer market that has outpaced the science. Both of those things are true. This site exists to document all of it — the benefits, the risks, and the evolving legal landscape — grounded in primary sources, not marketing or advocacy.
The legal picture is moving fast: 10 states have banned 7-OH, 12 regulate it under Kratom Consumer Protection Acts, and the FDA has recommended Schedule I placement — but the DEA has not acted. We track all 50 states and update when the law changes.
The concentration difference between the 7-OH that occurs naturally in a kratom leaf (<0.02% by weight) and the semi-synthetic 7-OH in a commercial tablet (up to 98% purity). That gap is what makes concentrated products effective for pain relief at low milligram doses — and it’s also the distinction driving every state-level regulatory debate. Understanding it is the starting point for everything else on this site. Our full guide covers the pharmacology, the market, and the regulatory picture.
Mitragynine (top, faded) → 7-OH (bottom, active)
Hydroxyl at position 7 is the difference
Where to start
Guide · 12 min read
What 7-OH is, how it works at the receptor, why it helps some people manage chronic pain, and why regulators are scrutinising the concentrated product market. Start here and the rest of the site makes sense.
Effects & safety
From mild mood lift and pain relief at low doses to heavy sedation at high doses. How the partial-agonist ceiling shapes both the benefits and the risks.
Comparison
Same plant, different delivery. How concentrated products compare to whole leaf in effects, onset, cost, and legal treatment.
States with restrictions
12 listed
7-OHMZ
Lab testedPioneer in isolated 7-hydroxymitragynine tablets
7PURE
Lab testedHigh-potency 7-OH for experienced users
Opia
Lab testedPremium 7-OH tablets with broad appeal
Hydroxie
Lab testedQuality 7-hydroxymitragynine products
7 Star
Lab testedRising star in the 7-OH market
Bars
Lab testedQuality and transparency above all else
Limitless
Lab testedPremium kratom and 7-OH extracts
7Tabz
Lab testedTop-tier kratom extract tablets
7OH+
Lab testedRefresh, relax, and relieve naturally
Deep dives
Comparisons