7-Hydroxy.co7-Hydroxymitragynine.co

Vol. 01Updated 14 Apr 2026Independent Resource

7-Hydroxymitragynine, explained.

The alkaloid reshaping the kratom market — and drawing scrutiny from regulators in 9 states. What the science says, what the law says, and what consumers need to know.

Read the guide Legal tracker

More potent than mitragynine: 46×
States legally tracked: 50
Cited primary sources: 26

§01

Start here

03 features

Guide · 12 min read

What is 7-Hydroxymitragynine?

A potent kratom alkaloid roughly 46× more active than mitragynine and 13× more active than morphine at the mu-opioid receptor. How it works, where it comes from, and why it's controversial.

Effects & safety

What does 7-OH actually do?

Dose-dependent effects from mild mood lift to heavy sedation.

Effects by dose

Comparison

7-OH vs traditional kratom

Isolated alkaloid vs full-spectrum leaf — the differences that matter.

§02

Legal status, by state

Banned: 9
Restricted: 2
Regulated: 10
Legal: 28

States with restrictions

11 listed

AlabamaAL ArkansasAR CaliforniaCA ConnecticutCT FloridaFL IndianaIN LouisianaLA OhioOH TennesseeTN VermontVT WisconsinWI

§03

Brand directory

· 9 reviewed

№BrandFormatsFounded

§04

Product formats

· 06 formats

Onset · 20–45 min

Most common; oral first-pass

Onset · 10–20 min

Liquid; sharp onset

Onset · 10–15 min

Sublingual fraction bypasses liver

Onset · 30–60 min

Food-matrix slows absorption

Onset · Variable

Concentrated; dose precision matters

Onset · 15–30 min

Requires mg scale for accuracy

§05

Keep reading

In this issue

Deep dives

Comparisons

Reference

7-Hydroxymitragynine.co · Vol. 01Editorial policyReferencesAbout